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Brim, Hassan

One or more keywords matched the following properties of Brim, Hassan

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overview	Research Interests: Genetics, Epigenetics and environmental factors in African American Colon Cancer Dr. Hassan Brim earned his PhD from the Free University of Brussels in the field of "Molecular Biology, Genetic Engineering and Environmental Microbiology." He then moved to the Naval Medical Center in Bethesda where he worked on the degradation and transformation of carcinogenic products in radioactive environments. This work was implemented in a radio resistant bacterium equipped with particular DNA repair mechanisms. This work has led to high profile publications in Nature Biotechnology and cited in Science Magazine. From there, Dr. Brim moved to study DNA repair in colon cancer specimens. He analyzed microsatellite instability, DNA methylation and chromosomal instability in colon cancer cases. He is currently addressing environmental factors that trigger and/or promote colon cancer among which the gut flora is a major player of which the role is yet to be defined. Dr. Brim is currently an Assistant professor at the Department of Pathology and has more than 30 publications.

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overview

Research Interests: Genetics, Epigenetics and environmental factors in African American Colon Cancer Dr. Hassan Brim earned his PhD from the Free University of Brussels in the field of "Molecular Biology, Genetic Engineering and Environmental Microbiology." He then moved to the Naval Medical Center in Bethesda where he worked on the degradation and transformation of carcinogenic products in radioactive environments. This work was implemented in a radio resistant bacterium equipped with particular DNA repair mechanisms. This work has led to high profile publications in Nature Biotechnology and cited in Science Magazine. From there, Dr. Brim moved to study DNA repair in colon cancer specimens. He analyzed microsatellite instability, DNA methylation and chromosomal instability in colon cancer cases. He is currently addressing environmental factors that trigger and/or promote colon cancer among which the gut flora is a major player of which the role is yet to be defined. Dr. Brim is currently an Assistant professor at the Department of Pathology and has more than 30 publications.

One or more keywords matched the following items that are connected to Brim, Hassan

Item Type	Name
Academic Article	SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas.
Academic Article	Distinct high-profile methylated genes in colorectal cancer.
Academic Article	Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients.
Academic Article	An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors.
Academic Article	A meta-analysis of MSI frequency and race in colorectal cancer.
Academic Article	Molecular Characterization of Sessile Serrated Adenoma/Polyps From a Large African American Cohort.
Academic Article	Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
Academic Article	Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans.
Academic Article	Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.
Concept	Microsatellite Instability
Academic Article	Saffron and Its Major Ingredients' Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite Instability.
Academic Article	High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer.

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Microsatellite Instability